Publications

Link for PubMed - https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40767526/?sort=date&direction=descending

Link for GRA - http://gra.org/scholar/89/Dennis_Kyle.html

Publications (since 2010)

Parvatkar PT, Maher SP, Zhao Y, Cooper CA, de Castro ST, Péneau J, Vantaux A, Witkowski B, Kyle DE, Manetsch R. (2024). In Vitro Antimalarial Activity of Trichothecenes against Liver and Blood Stages of Plasmodium Species. Journal of Natural Products, Feb 23;87(2):315-321. doi:https://10.1021/acs.jnatprod.3c01019

Shepherd RA., Earp CE., Cank KB., Raja HA., Burdette J., Maher SP., Martin AA., Ruberto AA., Mai SL., .....Oberlies NH. (2023). Sheptide A: an antimalarial cyclic pentapeptide from a fungal strain in the herpotrichiellaceae. The Journal of Antibiotics (Tokyo), 76(11):642-649. doi:s41429-023-00655-6

Maher SP., Bakowski MA., Vantaux A., Flannery EL., Andolina C., Gupta M., Antonova-Koch Y., Argomaniz M.,.....Kyle DE., (2023). A drug repurposing approach revelas targetable epigenetic pathways in Plasmodium vivax hypnozoites. BioRxiv, doi:2023.01.31.526483

Pathak AK., Shiau JC., Freitas RCS., Kyle DE., (2023). Blood meals from 'dead-end' vertebrate hosts enhance transmission potential of malaria-infected mosquitoes. One Health, 17:100582. doi:j.onehlt.2023.100582 

Bowers C., Hancox L., Peissig K., Shiau JC., Vantaux A., Witkowski B., Phal S., Maher SP., Harty JT., Kyle De., Kurup SP., (2022). Cryopreservation of Plasmodium sporozoites. Pathogens, 11(12):1497. doi:pathogens11121487

 Botnar A., Lawrence G., Maher SP., Vantaux B., Witkowski B., Shiau JC., Merino EF.,......Kyle DE., (2022). Alkyne modified purines for assessment of activation of Plasmodium vivax hypnozoites and growth   of pre-erythrocytic stages in Plasmodium spp. International Journal for Parasitology, 52(11):733-744. doi:j.ijpara.2022.03.003

 Pathak AK., Shiau JC., Frnake-Fayard B., Shollenberger LM., Harn DA., Kyle De., Murdock CC., (2022). Streamlining sporozoite isolation from mosquitoes by leveraging the dynamics of migration to the  salivary glands. Malaria Journal 21(1): doi:s12936-022-04270-y

 Ruberto AA., Maher SP., Vantaux A., Joyner CJ., Bourke C., Balan B., Jex A., Mueller I., Witkowski B., Kyle DE., (2022). Single-cell RNA Profiling of Plasmodium vivax-infected hepatocytes reveals parasite-  and-host-specific transcriptomic signatures and theraputic targets. Frontiers in cellular and  infection microbiology, 12:986314. doi:fcimb.2022.986314 

 Dong Y., Sonawane Y., Maher SP., Zeeman AM., Chaumeau V., Vantaux A., Cooper CA., Chiu FCK,. ......Vennerstrom JL., (2022). Metabolic, pharmacokinetic, and activity profile of the liver stage  antimalarial (RC-12). ACS Omega, 7(14):12401-12411. doi:acsomega.2c01099

 Phan IQ, Rice CA., Craig J., Noorai RE., McDonald JR., Subramanian S., Tillery l., Barrett LK., Shankar V., Morris JC., Van Voorhis WC., Kyle DE., Myler PJ., (2021). The Transcriptome of Balamuthia  mandrillaris trophozoites for structure-guided drug design. Science Reports 11(1):21664. doi:s41598-021-99903-8

 Lichorowic CL., Zhao Y., Maher SP., Padin-Irizarry V., Mendiola VC., de Castro ST., Worden JA., Kyle DE., Manetsch R. (2021). Synthesis of mono-and bisperoxide-bridged artemisinin dimers to elucidate  the contribution of dimerization to antimalarial activity. ACS Infectious Diseases, 7(7):2013-2024. doi:acsinfecdis.1c00066

 Troth EV., Kyle DE., (2021). Edu incorporation to assess cell proliferation and drug susceptibility in Naegeria fowleri.. Antimicrobial Agents and Chemotherapy,65(7). doi:10.1128/aac.00017-21

 Sylvester K., Maher SP., Posfai D., Tran MK., Crawford MC., Vantaux A., Witkowski B., Kyle DE., Derbyshire ER., (2021), Characterization of the tubular network in Plasmodium vivax liver stage hypnozoites  and schizonts. Frontiers in Cellular and Infection Microbiology ,1:687019. doi:10.3389/fcimb.2021.687019

 Rice CA.,, Colon BL., Chen E., Hull MV., Kyle DE., (2020) Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoeba. PloS neglected Tropical Diseases, 14(9). doi10.1371/journal.pntd.0008353

 Posfai D., Maher SP., Roesch C., Vantaux A., Sylvester K., Peneau J., Popovici J., Kyle DE., Witkowski B., Derbyshire ER., (2020), Plasmodium vivx liver and blood stages recruit the druggable host membrane channel aquporin-3. Cell Chemical Biology, 27(6) 719-727. doi:10.1016/j.chembiol.2020.03.009 

Chua ACY., Ong JJY, Malleret B., Suwanarusk r., Kosaisavee V., Zeeman AM., Cooper CA., Tan KSW., Zhang R., Tan BH., Abas SN., Yip A., Elliot A., Joyner CJ., Cho JS., Breyer K., Baran S., Lange A., Maher SP. Nosten F., Bodenreider C., Yeung BKS., Mazier D., Galinski MR., Dereuddre-Bosquet N., Le Grand R., Kocken CHM., Kyle DE., Diagana TT., Snounou G., Bifani P.,  (2019). Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages. Nature Communications, 10 (1)  doi:10.1038/s41467-019-11332-4 

Obaldia, N., Milhous, W. K., & Kyle, D. E. (2018). Reversal of chloroquine resistance of Plasmodium vivax in Aotus monkeys.. Antimicrobial agents and chemotherapy. doi:10.1128/aac.00582-18

Roth, A., Maher, S. P., Conway, A. J., Ubalee, R., Chaumeau, V., Andolina, C., . . . Adams, J. H. (2018). Author Correction: A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum. Nature Communications, 9(1). doi:10.1038/s41467-018-04817-1

Roth, A., Maher, S. P., Conway, A. J., Ubalee, R., Chaumeau, V., Andolina, C., . . . Adams, J. H. (2018). A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum. Nature Communications, 9(1). doi:10.1038/s41467-018-04221-9

Siegel, S. V., Rivero, A. V., Oberstaller, J., Colon, B. L., de Buron, I., & Kyle, D. E. (2018). Blood flukes Cardicola parvus and C. laruei (Trematoda: Aporocotylidae): life cycles and cryptic infection in spotted seatrout, Cynoscion nebulosus (Teleost: Sciaenidae). Parasitology International, 67(2), 150-158. doi:10.1016/j.parint.2017.10.012

Duvalsaint, M., & Kyle, D. E. (2018). Phytohormones, Isoprenoids, and Role of the Apicoplast in Recovery from Dihydroartemisinin-Induced Dormancy of Plasmodium falciparum.. Antimicrob Agents Chemother, 62(3). doi:10.1128/AAC.01771-17

Thomas, S. A. L., von Salm, J. L., Clark, S., Ferlita, S., Nemani, P., Azhari, A., . . . Baker, B. J. (2018). Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima.. Journal of natural products,81(1), 117-123. doi:10.1021/acs.jnatprod.7b00732

Neelarapu, R., Maignan, J. R., Lichorowic, C. L., Monastyrskyi, A., Mutka, T. S., LaCrue, A. N., . . . Manetsch, R. (2018). Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1 H )-Quinolones with Potent Antimalarial Activity: Structure–Activity and Structure–Property Relationship Studies. Journal of Medicinal Chemistry, 61(4), 1450-1473. doi:10.1021/acs.jmedchem.7b00738

Siegel, S., Rivero, A., Adapa, S., Wang, C., Manetsch, R., Jiang, R. H. Y., & Kyle, D. E. (2017). Mitochondrial heteroplasmy is responsible for Atovaquone drug resistance in Plasmodium falciparum. BioRxiv. doi:10.1101/232033

McQueen, A., Blake, L. D., Azhari, A., Kemp, M. T., McGaha, T. W., Namelikonda, N., . . . Kyle, D. E. (2017). Synthesis, characterization, and cellular localization of a fluorescent probe of the antimalarial 8-aminoquinoline primaquine. Bioorganic & Medicinal Chemistry Letters, 27(20), 4597-4600. doi:10.1016/j.bmcl.2017.09.030

Kanwar, A., Eduful, B. J., Barbeto, L., Carletti Bonomo, P., Lemus, A., Vesely, B. A., . . . Leahy, J. W. (2017). Synthesis and Activity of a New Series of Antileishmanial Agents. ACS Medicinal Chemistry Letters, 8(8), 797-801. doi:10.1021/acsmedchemlett.7b00039

Kosaisavee, V., Suwanarusk, R., Chua, A. C. Y., Kyle, D. E., Malleret, B., Zhang, R., . . . Russell, B. (2017). Strict tropism for CD71 +  /CD234  + human reticulocytes limits the zoonotic potential of  Plasmodium cynomolgi  . Blood, 130(11), 1357-1363. doi:10.1182/blood-2017-02-764787

Wirjanata, G., Handayuni, I., Prayoga, P., Leonardo, L., Apriyanti, D., Trianty, L., . . . Marfurt, J. (2017). Plasmodium falciparum and Plasmodium vivax Demonstrate Contrasting Chloroquine Resistance Reversal Phenotypes. Antimicrobial Agents and Chemotherapy, 61(8), e00355-17. doi:10.1128/AAC.00355-17

Blake, L. D., Johnson, M. E., Siegel, S. V., McQueen, A., Iyamu, I. D., Shaikh, A. K., . . . Kyle, D. E. (2017). Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome b  That Are Transmissible through Mosquitoes . Antimicrobial Agents and Chemotherapy, 61(8), e00689-17. doi:10.1128/AAC.00689-17

Giulianotti, M. A., Vesely, B. A., Azhari, A., Souza, A., LaVoi, T., Houghten, R. A., . . . Leahy, J. W. (2017). Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries. ACS Medicinal Chemistry Letters, 8(8), 802-807. doi:10.1021/acsmedchemlett.7b00045

Van Voorhis, W. C., Adams, J. H., Adelfio, R., Ahyong, V., Akabas, M. H., Alano, P., . . . Willis, P. A. (2016). Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLOS PATHOGENS, 12(7). doi:10.1371/journal.ppat.1005763

Roberts, B. F., Iyamu, I. D., Lee, S., Lee, E., Ayong, L., Kyle, D. E., . . . Chakrabarti, D. (2016). Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages. International Journal for Parasitology: Drugs and Drug Resistance, 6(1), 85-92. doi:10.1016/j.ijpddr.2016.02.004

Waterman, C., Calcul, L., Beau, J., Ma, W. S., Lebar, M. D., von Salm, J. L., . . . Baker, B. J. (2016). Miniaturized Cultivation of Microbiota for Antimalarial Drug Discovery. Medicinal Research Reviews, 36(1), 144-168. doi:10.1002/med.21335

Maignan, J. R., Lichorowic, C. L., Giarrusso, J., Blake, L. D., Casandra, D., Mutka, T. S., . . . Manetsch, R. (2016). ICI 56,780 Optimization: Structure–Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1 H )-quinolones with Antimalarial Activity. Journal of Medicinal Chemistry, 59(14), 6943-6960. doi:10.1021/acs.jmedchem.6b00759

Baragaña, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., . . . Gilbert, I. H. (2016). Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature, 537(7618), 122. doi:10.1038/nature18280

Van Horn, K. S., Zhu, X., Pandharkar, T., Yang, S., Vesely, B., Vanaerschot, M., . . . Manetsch, R. (2016). Correction to Antileishmanial Activity of a Series of N 2 , N 4 -Disubstituted Quinazoline-2,4-diamines. Journal of Medicinal Chemistry, 59(2), 775. doi:10.1021/acs.jmedchem.5b00981

Obaldía III, N., Dow, G. S., Gerena, L., Kyle, D., Otero, W., Mantel, P. -Y., . . . Marti, M. (2016). Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model. Scientific Reports, 6(1). doi:10.1038/srep21216

Hott, A., Tucker, M. S., Casandra, D., Sparks, K., & Kyle, D. E. (2015). Fitness of artemisinin-resistant Plasmodium falciparum in vitro. Journal of Antimicrobial Chemotherapy, 70(10), 2787-2796. doi:10.1093/jac/dkv199

Pradhan, A., Siwo, G. H., Singh, N., Martens, B., Balu, B., Button-Simons, K. A., . . . Kyle, D. E. (2015). Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery. Scientific Reports, 5(1). doi:10.1038/srep15930

Rice, C. A., Colon, B. L., Alp, M., Göker, H., Boykin, D. W., & Kyle, D. E. (2015). Bis-Benzimidazole Hits against Naegleria fowleri Discovered with New High-Throughput Screens. Antimicrobial Agents and Chemotherapy, 59(4), 2037-2044. doi:10.1128/AAC.05122-14

Shao, C. -L., Linington, R. G., Balunas, M. J., Centeno, A., Boudreau, P., Zhang, C., . . . Gerwick, W. H. (2015). Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. The Journal of Organic Chemistry, 80(16), 7849-7855. doi:10.1021/acs.joc.5b01264

Hott, A., Casandra, D., Sparks, K. N., Morton, L. C., Castanares, G. -G., Rutter, A., & Kyle, D. E. (2015). Artemisinin-Resistant Plasmodium falciparum Parasites Exhibit Altered Patterns of Development in Infected Erythrocytes. Antimicrobial Agents and Chemotherapy, 59(6), 3156-3167. doi:10.1128/AAC.00197-15

Baragaña, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., . . . Gilbert, I. H. (2015). A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature, 522(7556), 315-320. doi:10.1038/nature14451

von Salm, J. L., Wilson, N. G., Vesely, B. A., Kyle, D. E., Cuce, J., & Baker, B. J. (2014). Shagenes A and B, New Tricyclic Sesquiterpenes Produced by an Undescribed Antarctic Octocoral. Organic Letters, 16(10), 2630-2633. doi:10.1021/ol500792x

Cross, R. M., Flanigan, D. L., Monastyrskyi, A., LaCrue, A. N., Sáenz, F. E., Maignan, J. R., . . . Manetsch, R. (2014). Orally Bioavailable 6-Chloro-7-methoxy-4(1 H )-quinolones Efficacious against Multiple Stages of Plasmodium. Journal of Medicinal Chemistry, 57(21), 8860-8879. doi:10.1021/jm500942v

Maher, S. P., Crouse, R. B., Conway, A. J., Bannister, E. C., Achyuta, A. K. H., Clark, A. Y., . . . Saadi, W. M. (2014). Microphysical space of a liver sinusoid device enables simplified long-term maintenance of chimeric mouse-expanded human hepatocytes. Biomedical Microdevices, 16(5), 727-736. doi:10.1007/s10544-014-9877-x

Rojas-Silva, P., Graziose, R., Vesely, B., Poulev, A., Mbeunkui, F., Grace, M. H., . . . Raskin, I. (2014). Leishmanicidal activity of a daucane sesquiterpene isolated from Eryngium foetidum. Pharmaceutical Biology, 52(3), 398-401. doi:10.3109/13880209.2013.837077

Chen, N., LaCrue, A. N., Teuscher, F., Waters, N. C., Gatton, M. L., Kyle, D. E., & Cheng, Q. (2014). Fatty Acid Synthesis and Pyruvate Metabolism Pathways Remain Active in Dihydroartemisinin-Induced Dormant Ring Stages of Plasmodium falciparum. Antimicrobial Agents and Chemotherapy, 58(8), 4773-4781. doi:10.1128/AAC.02647-14

Henrich, P. P., O'Brien, C., Saenz, F. E., Cremers, S., Kyle, D. E., & Fidock, D. A. (2014). Evidence for Pyronaridine as a Highly Effective Partner Drug for Treatment of Artemisinin-Resistant Malaria in a Rodent Model. Antimicrobial Agents and Chemotherapy, 58(1), 183-195. doi:10.1128/AAC.01466-13

Van Horn, K. S., Zhu, X., Pandharkar, T., Yang, S., Vesely, B., Vanaerschot, M., . . . Manetsch, R. (2014). Antileishmanial Activity of a Series of N 2 , N 4 -Disubstituted Quinazoline-2,4-diamines. Journal of Medicinal Chemistry,57(12), 5141-5156. doi:10.1021/jm5000408

Monastyrskyi, A., Kyle, D. E., & Manetsch, R. (2014). 4(1H)-pyridone and 4(1H)-quinolone derivatives as antimalarials with erythrocytic, exoerythrocytic, and transmission blocking activities.. Current topics in medicinal chemistry,14(14), 1693-1705. doi:10.2174/1568026614666140808124638

Jiménez-Díaz, M. B., Ebert, D., Salinas, Y., Pradhan, A., Lehane, A. M., Myrand-Lapierre, M. -E., . . . Guy, R. K. (2014). (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium. Proceedings of the National Academy of Sciences, 111(50), E5455-E5462. doi:10.1073/pnas.1414221111

Calcul, L., Waterman, C., Ma, W., Lebar, M., Harter, C., Mutka, T., . . . Baker, B. (2013). Screening Mangrove Endophytic Fungi for Antimalarial Natural Products. Marine Drugs, 11(12), 5036-5050. doi:10.3390/md11125036

Srivastava, A., Sweat, J. M., Azizan, A., Vesely, B., & Kyle, D. E. (2013). Real-Time PCR to Quantify Leishmania donovani in Hamsters. Journal of Parasitology,99(1), 145-150. doi:10.1645/GE-3221.1

Nilsen, A., LaCrue, A. N., White, K. L., Forquer, I. P., Cross, R. M., Marfurt, J., . . . Riscoe, M. K. (2013). Quinolone-3-Diarylethers: A New Class of Antimalarial Drug. Science Translational Medicine, 5(177), 177ra37. doi:10.1126/scitranslmed.3005029

LaCrue, A. N., Saenz, F. E., Cross, R. M., Udenze, K. O., Monastyrskyi, A., Stein, S., . . . Kyle, D. E. (2013). 4(1H)-Quinolones with Liver Stage Activity against Plasmodium berghei. Antimicrobial Agents and Chemotherapy, 57(1), 417-424. doi:10.1128/AAC.00793-12

Saenz, F. E., LaCrue, A. N., Cross, R. M., Maignan, J. R., Udenze, K. O., Manetsch, R., & Kyle, D. E. (2013). 4-(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-Ones Prevent the Transmission of Plasmodium falciparum to Anopheles freeborni. Antimicrobial Agents and Chemotherapy, 57(12), 6187-6195. doi:10.1128/AAC.00492-13

Teuscher, F., Chen, N., Kyle, D. E., Gatton, M. L., & Cheng, Q. (2012). Phenotypic Changes in Artemisinin-Resistant Plasmodium falciparum Lines In Vitro: Evidence for Decreased Sensitivity to Dormancy and Growth Inhibition. Antimicrobial Agents and Chemotherapy, 56(1), 428-431. doi:10.1128/AAC.05456-11

Tucker, M. S., Mutka, T., Sparks, K., Patel, J., & Kyle, D. E. (2012). Phenotypic and Genotypic Analysis of In Vitro-Selected Artemisinin-Resistant Progeny of Plasmodium falciparum. Antimicrobial Agents and Chemotherapy, 56(1), 302-314. doi:10.1128/AAC.05540-11

Saenz, F. E., Mutka, T., Udenze, K., Oduola, A. M. J., & Kyle, D. E. (2012). Novel 4-Aminoquinoline Analogs Highly Active against the Blood and Sexual Stages of Plasmodium In Vivo and In Vitro. Antimicrobial Agents and Chemotherapy, 56(9), 4685-4692. doi:10.1128/AAC.01061-12

Lowes, D., Pradhan, A., Iyer, L. V., Parman, T., Gow, J., Zhu, F., . . . Guy, R. K. (2012). Lead Optimization of Antimalarial Propafenone Analogues. Journal of Medicinal Chemistry, 55(13), 6087-6093. doi:10.1021/jm300286a

Zhang, Y., Clark, J. A., Connelly, M. C., Zhu, F., Min, J., Guiguemde, W. A., . . . Guy, R. K. (2012). Lead Optimization of 3-Carboxyl-4(1 H )-Quinolones to Deliver Orally Bioavailable Antimalarials. Journal of Medicinal Chemistry,55(9), 4205-4219. doi:10.1021/jm201642z

Beau, J., Mahid, N., Burda, W. N., Harrington, L., Shaw, L. N., Mutka, T., . . . Baker, B. J. (2012). Epigenetic Tailoring for the Production of Anti-Infective Cytosporones from the Marine Fungus Leucostoma persoonii. Marine Drugs, 10(12), 762-774. doi:10.3390/md10040762

Balunas, M. J., Grosso, M. F., Villa, F. A., Engene, N., McPhail, K. L., Tidgewell, K., . . . Gerwick, W. H. (2012). Coibacins A–D, Antileishmanial Marine Cyanobacterial Polyketides with Intriguing Biosynthetic Origins. Organic Letters, 14(15), 3878-3881. doi:10.1021/ol301607q

Cheng, Q., Kyle, D. E., & Gatton, M. L. (2012). Artemisinin resistance in Plasmodium falciparum: A process linked to dormancy?. International Journal for Parasitology: Drugs and Drug Resistance, 2, 249-255. doi:10.1016/j.ijpddr.2012.01.001

Kaewpongsri, S., Sriprawat, K., Suwanarusk, R., Kyle, D. E., Lek-Uthai, U., Leimanis, M., . . . Renia, L. (2011). The Presence of Leukocytes in Ex Vivo Assays Significantly Increases the 50-Percent Inhibitory Concentrations of Artesunate and Chloroquine against Plasmodium vivax and Plasmodium falciparum. Antimicrobial Agents and Chemotherapy, 55(3), 1300-1304. doi:10.1128/AAC.01103-10

Cross, R. M., Namelikonda, N. K., Mutka, T. S., Luong, L., Kyle, D. E., & Manetsch, R. (2011). Synthesis, Antimalarial Activity, and Structure–Activity Relationship of 7-(2-Phenoxyethoxy)-4(1 H )-quinolones. Journal of Medicinal Chemistry, 54(24), 8321-8327. doi:10.1021/jm200718m

Dow, G. S., Gettayacamin, M., Hansukjariya, P., Imerbsin, R., Komcharoen, S., Sattabongkot, J., . . . Ohrt, C. (2011). Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta). Malaria Journal, 10(1), 212. doi:10.1186/1475-2875-10-212

Cross, R. M., Maignan, J. R., Mutka, T. S., Luong, L., Sargent, J., Kyle, D. E., & Manetsch, R. (2011). Optimization of 1,2,3,4-Tetrahydroacridin-9(10 H )-ones as Antimalarials Utilizing Structure–Activity and Structure–Property Relationships. Journal of Medicinal Chemistry, 54(13), 4399-4426. doi:10.1021/jm200015a

LaCrue, A. N., Scheel, M., Kennedy, K., Kumar, N., & Kyle, D. E. (2011). Effects of Artesunate on Parasite Recrudescence and Dormancy in the Rodent Malaria Model Plasmodium vinckei. PLoS ONE, 6(10), e26689. doi:10.1371/journal.pone.0026689

Lebar, M. D., Hahn, K. N., Mutka, T., Maignan, P., McClintock, J. B., Amsler, C. D., . . . Baker, B. J. (2011). CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs. Bioorganic & Medicinal Chemistry, 19(19), 5756-5762. doi:10.1016/j.bmc.2011.08.033

Codd, A., Teuscher, F., Kyle, D. E., Cheng, Q., & Gatton, M. L. (2011). Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure. Malaria Journal, 10(1), 56. doi:10.1186/1475-2875-10-56

Zhu, X., Banerjee, M., Farhat, A. A., Reid, C., Pandharkar, T., Patrick, D. A., . . . Werbovetz, K. (2010). ANTILEISHMANIAL ACTIVITY OF NOVEL ARYLIMIDAMIDES. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENEVol. 83 (pp. 71). Atlanta, GA: AMER SOC TROP MED & HYGIENE. Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295819700239&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=bccb20a1f2d949998a887c45eb30dd98

Chavchich, M., Gerena, L., Peters, J., Chen, N., Cheng, Q., & Kyle, D. E. (2010). Role of pfmdr1 Amplification and Expression in Induction of Resistance to Artemisinin Derivatives in Plasmodium falciparum. Antimicrobial Agents and Chemotherapy, 54(6), 2455-2464. doi:10.1128/AAC.00947-09

Wang, M. Z., Zhu, X., Srivastava, A., Liu, Q., Sweat, J. M., Pandharkar, T., . . . Werbovetz, K. A. (2010). Novel Arylimidamides for Treatment of Visceral Leishmaniasis. Antimicrobial Agents and Chemotherapy, 54(6), 2507-2516. doi:10.1128/AAC.00250-10

Cross, R. M., Monastyrskyi, A., Mutka, T. S., Burrows, J. N., Kyle, D. E., & Manetsch, R. (2010). Endochin Optimization: Structure−Activity and Structure−Property Relationship Studies of 3-Substituted 2-Methyl-4(1 H )-quinolones with Antimalarial Activity. Journal of Medicinal Chemistry,53(19), 7076-7094. doi:10.1021/jm1007903

Balunas, M. J., Linington, R. G., Tidgewell, K., Fenner, A. M., Ureña, L. -D., Togna, G. D., . . . Gerwick, W. H. (2010). Dragonamide E, a Modified Linear Lipopeptide from Lyngbya majuscula with Antileishmanial Activity. Journal of Natural Products, 73(1), 60-66. doi:10.1021/np900622m

Chen, N., Chavchich, M., Peters, J. M., Kyle, D. E., Gatton, M. L., & Cheng, Q. (2010). Deamplification of pfmdr1-Containing Amplicon on Chromosome 5 in Plasmodium falciparum Is Associated with Reduced Resistance to Artelinic Acid In Vitro. Antimicrobial Agents and Chemotherapy, 54(8), 3395-3401. doi:10.1128/AAC.01421-09

Teuscher, F., Gatton, M., Chen, N., Peters, J., Kyle, D., & Cheng, Q. (2010). Artemisinin‐Induced Dormancy in Plasmodium falciparum : Duration, Recovery Rates, and Implications in Treatment Failure. The Journal of Infectious Diseases, 202(9), 1362-1368. doi:10.1086/656476

Sanchez, L. M., Lopez, D., Vesely, B. A., Della Togna, G., Gerwick, W. H., Kyle, D. E., & Linington, R. G. (2010). Almiramides A−C: Discovery and Development of a New Class of Leishmaniasis Lead Compounds. Journal of Medicinal Chemistry,53(10), 4187-4197. doi:10.1021/jm100265s